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Contraindicated (one)pentobarbital decreases levels of vandetanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration with powerful CYP3A4 inducers; these prescription drugs lessen exposure to vandetanib by around 40%.pentobarbital will decrease the level or impact of amlodipine by impacting